ABACUS (Alerts Based on ADR Causality and Severity)
|Is there a reasonable time interval between administration of the suspected drug and the adverse reaction?
|Has the adverse reaction been associated with the suspected drug before?
|Could this adverse reaction be due to an existing clinical condition?
|Is there any over-dose of the suspected drug?
|If the drug was discontinued, did the adverse reaction improve within a reasonable period of time?
|If the drug was NOT discontinued, did the reaction resolved on its own?
|Did the reaction improve when specific antagonist/antidote towards the suspected drug was administered?
|Did the adverse reaction recur when the suspected drug was discontinued and re-administered?
|Offending drug may or may not be withheld, no treatment required
|Offending drug to be withheld, out-patient treatment is required
|Offending drug to be withheld, in-patient treatment is required
|Intensive care is required but patient does not suffer any disability
|Patient suffer irreversible harm (including physical disability)
|Patient died as a result of the reaction (either directly or indirectly)
ABACUS was developed in collaboration with Professor Shu-Chuen Li from University of Newcastle, Australia and Dr Yvonne Koh from National University of Singapore.
Please cite using: Koh Y, Yap CW, Li SC (2010). Development of a combined system for identification and classification of adverse drug reactions: Alerts Based on ADRs' Causality and Severity (ABACUS). Journal of the American Medical Informatics Association 17 (6): 720-722
Last modified on 7 February, 2012 by Yap Chun Wei